Hypersensitivity pneumonitis induced by trimethoprim.

intracranial course. The sixth nerve occupies a superficial position in relation to the fourth ventricle, which communicates directly through the foramina of Magendie and Luschka with the subarachnoid space. Dye studies have shown that agents introduced into the spinal canal frequently reach the medulla, which may explain the peculiar affinity of the sixth nerve to palsy.4 The contrast agents introduced in the procedure of myelography have a toxicity of their own, and the incidence of cranial nerve palsy is higher than after merely dural puncture.5 This may be due to a previously unreported direct neurotoxicity of the contrast agent iopamidol itself.